University of Switzerland DEGREES

University of Switzerland’s Graduate Course Descriptions

Biochemistry and Molecular Biology/BMB

Note: See quarterly class schedule or departmental advisor for further enrollment restrictions, requirements, or special course information. 

510     INTRODUCTORY BIOCHEMISTRY (5.5)

Introduction to general principles of biochemistry, especially for students interested in the allied health sciences. Topics include the chemistry of biological molecules, cellular metabolism, and the mode of action of selected chemicals at the biochemical level. Not open to graduate students in the College of Science and Mathematics.

PREREQUISITE: CHM 102 OR 141.

627     HUMAN BIOCHEMISTRY (4.5)

Metabolism of hormones and amino acids.Integration of metabolism.Aspects of human biochemistry including some metabolic disorders and nutrition.

651     RECENT DEVELOPMENTS IN BIOCHEMISTRY (3)

Detailed consideration of major research developments in biochemistry within the past several months.Discussion will deal not only with the appropriate research papers but also with the background information such articles leave out.

PREREQUISITE: BMB(BCH) 621; OR BMB(BCH)/BMS 751 AND 752; OR CONSENT OF PROFESSOR.

699     SPECIAL PROBLEMS IN BIOCHEMISTRY (1 TO 4)

Graded pass/unsatisfactory.

702     RESEARCH PERSPECTIVES (4)

Designed to acquaint new graduate students with the research being carried out by the faculty in the biochemistry program.

703     RESEARCH ETHICS (1)

(Also listed as BMS 703.) Research ethics emphasizes the evaluation of hypothetical ethical scenarios. Class discussion is based on integrating ethical policy and practices as they relate to research at Wright State. Graded pass/unsatisfactory.

726     BIOENERGETICS (1 TO 6)

Structure of energy transducing membranes of mitochondria, chloroplasts and bacteria.Particular emphasis placed on mechanisms of energy transduction, thermodynamics of oxidation-reduction reactions, biophysical spectroscopic methods, structure and surface topography of membrane proteins.

PREREQUISITE: BMS 752.

727     ENZYMES (4)

(Also listed as BMS 767.) Current concepts of the mechanism of enzyme catalysis including such topics as structure, kinetics, energetics, allosterism, coenzymes, and control of enzymes and multienzyme systems.

PREREQUISITE: BMB(BCH) 750 OR CONSENT OF PROFESSOR.

729     BIOCHEMISTRY OF PEPTIDE HORMONES (3)

The synthesis, secrection, degradation, structure, essay, mechanism of action and function of peptide hormones are presented.Emphasis is on insulin and other hormones (e.g., glucagon, somatotropin, somatostatin) involved in diabetes mellitus.

PREREQUISITE: BMB(BCH) 621 OR EQUIVALENT.

731     BIOCHEMISTRY OF MEMBRANES (4)

(Also listed as BMS 769.) Examines the biochemistry of membranes and provides basic information on membrane composition and processes.

PREREQUISITE: BMB(BCH) 421 OR 423.

736     RECOMBINANT DNA METHODS (6)

Microbial and molecular techniques for producing, cloning and characterizing recombinant DNA molecules; laboratory exercises in gene manipulation to give an understanding of principles of genetic engineering.

PREREQUISITE: BMS 750, BMS 752, BIO 654 OR BMS 791, BIO 734 OR BMS 779, OR CONSENT OF PROFESSOR.

740     PHYSICAL BIOCHEMISTRY (4)

(Also listed as BMS 770.) Structure-function analysis of biological macromolecules (particularly proteins and polynucleotides) based on chemical and physical properties.

PREREQUISITE: BMB(BCH) 750 OR EQUIVALENT.

750     MOLECULAR BIOCHEMISTRY I (1 TO

(Also listed as BMS 750.) Survey course emphasizing an experimental and problem-solving approach to buffers, protein structure, enzymes, and carbohydrate and lipid metabolism. Completion of organic chemistry course or permission of professor required.

PREREQUISITE: ORGANIC CHEMISTRY OR PERMISSION OF PROFESSOR.

752     MOLECULAR BIOCHEMISTRY II (1 TO

(Also listed as BMS 752.) Survey course emphasizing an experimental and problem-solving approach to amino acid metabolism, nucleic-acid function, and hormones.

PREREQUISITE: BMB(BCH) 750 OR PERMISSION OF PROFESSOR.

753     MOLECULAR SIGNALLING-MOLECULAR CELL BIOLOGY (3)

(Also listed as BMS 753.) A molecular analysis of information transfer into and within cells. Topics include visual transduction, hormones, hormone receptors, second messengers, regulation of transcription, and oncogenes. Readings from current scientific literature.

PREREQUISITE: BMB(BCH)/BMS 750, BMB(BCH)/BMS 752.

755     CANCER: MOLECULAR ASPECTS (3)

A profile of the general properties of transformed cells and an in-depth examination of the mechanisms of oncogenesis at the level of molecular genetics.

PREREQUISITE: BMB 750.

760     MOLECULAR BIOLOGY OF THE NUCLEUS (4)

(Also listed as BMS 760.) A literature based course covering molecular events in the nucleus including DNA replication, repair and recombination and transcription.

PREREQUISITE: BMB 750, BMB 752.

762     FUNDAMENTAL PRINCIPLES OF FOURIER TRANSFORM NMR (3 TO 6)

(Also listed as BMS 762/PHY 760.) Covers the fundamental theory of nuclear magnetic resonance spectroscopy with emphasis on pulse Fourier transform methods.

PREREQUISITE: ORGANIC CHEMISTRY, PHY 111, 112, 113 OR EQUIVALENT; MTH 229, 230 OR EQUIVALENT; OR EQUIVALENT.

763     IN VIVO NMR SPECTROSCOPY AND IMAGING (3 TO 6)

(Also listed as BMS 763.) Discusses the applications of NMR spectroscopy to the study of tissue metabolism in vivo. The fundamental theory of magnetic resonance imaging, with a survey of clinical applications, is also presented.

PREREQUISITE: BMB(BCH)/BMS 762 OR PERMISSION OF PROFESSOR.

764     NMR TECHNIQUES IN BIOMOLECULAR STRUCTURE AND DYNAMICS (3 TO 6)

(Also listed as BMS 764.) Describes the NMR methods used for the determination of biomolecular structure and dynamics. Emphasis on two-dimensional Fourier transform techniques.

PREREQUISITE: BMB(BCH)/BMS 762 OR PERMISSION OF PROFESSOR.

765     COMPUTATIONAL TOOLS AND STRATEGIES IN BIOMED SCIENCES (4)

This is a survey course of modern computational tools and strategies used in sequence, 3-D structure and functional analysis of biomolecules.Students will gain hands on “laboratory” experience with key software and strategies.

800     BIOCHEMISTRY SEMINAR (1)

Topics vary. Graded pass/unsatisfactory.

899     BIOCHEMISTRY RESEARCH (1 TO 15)

Supervised thesis research.

900     SEMINAR IN BIOLOGICAL CHEMISTRY (1 TO 2)

Topics vary. Graded pass/unsatisfactory.

Biological Sciences/BIO

Note: See quarterly class schedule or departmental advisor for further enrollment restrictions, requirements, or special course information. 

521     HUMAN GENETICS FOR HEALTH PROFESSIONALS (3)

Describes mechanisms of inheritance and genetic diseases so that health professionals can recognize possible genetic abnormalities and make appropriate referrals, participate in genetic counseling, and consider ethical and legal implications of the “new genetics.” For nonmajors only.

PREREQUISITE: BIO 112 OR EQUIVALENT.

603     DEVELOPMENTAL BIOLOGY (5)

(Also listed as BMS 839.) Describes underlying processes that initiate, in plants and animals, the development of tissue and whole organisms.

PREREQUISITE: RECOMMENDED BIO 402, 303 OR THE EQUIVALENT.

606     EVOLUTIONARY BIOLOGY (3)

Historical development and current understanding of the principles of evolution.

PREREQUISITE: BIO 212 OR CONSENT OF PROFESSOR.

607     WETLANDS BIOLOGY (5)

Ecological investigation of wetlands of the U.S. with emphasis on the Midwest. Primarily field oriented with some lecture. Covers soils, vegetation, hydrology, conservation, and restoration. Requires two weekend trips and written report.

PREREQUISITE: JUNIOR OR SENIOR STANDING; CHM 121, ONE OF THE FOLLOWING: ECOLOGY, VASCULAR PLANTS, HYDROGEOLOGY OR SOIL BIOLOGY, AQUATIC BIOLOGY OR RELEVANT FIELD EXPERIENCES.

608     WRITING IN THE BIOLOGICAL SCIENCES (3)

Surveys grammatical and stylistic aspects of scientific writing and teaches how to organize, write, and submit a manuscript for publication in a biological journal. Grant writing is also discussed.

PREREQUISITE: BIO 112, 114 AND 115.

611     THE AQUATIC ENVIRONMENT (6)

Field and laboratory course concerned with the physical, chemical, and biological factors that determine biological productivity in natural waters. 3 hours lecture, 6 hours lab.

612     AQUATIC COMMUNITIES (6)

An analysis of the functional relationships of organisms with the aquatic environment with special emphasis on species interactions.

613     BIOLOGICAL PROBLEMS OF WATER POLLUTION (5)

Introduction to the biological aspects of water pollution. Lectures, discussions, laboratories, and field trips cover the various types of pollutants and their impact on aquatic life. 3 hours lecture, 4 hours lab, required field trips.

615     ENVIRONMENTAL TOXICOLOGY (4)

Covers toxicological problems encountered in the field of environmental health. Emphasis on monitoring, control, and regulation of toxic substances in air and water, and in industrial environments. 3 hours lecture, 1 hour recitation.

PREREQUISITE: A COURSE IN PHYSIOLOGY AND ORGANIC CHEMISTRY.

616     ECOTOXICOLOGY (4)

Study of the effects of environmental contaminants on aquatic and terrestrial organisms. Effects on the biochemical and physiological levels are related to impacts on individuals, populations, and ecosystems. Current approaches for assessing ecotoxicity are presented

PREREQUISITE: BIO 278 AND CHM 211.

620     DESIGNING BIOLOGICAL EXPERIMENTS (3)

Principles of effective sampling design for biological experiments. Reconciling the peculiarities of biological data with the assumptions of statistical methods. Lectures and problem sets.

PREREQUISITE: TWO BIOLOGY COURSES AT 300 OR ABOVE LEVEL, ONE COURSE IN STATISTICS.

625     MICROBIAL ECOLOGY (5)

(Also listed as BMS 793.) Microbes in soil, water, and air. Experiments on mineral cycles, physical and biological limiting factors, and symbiosis. Natural communities of microbes and microbes of special human environments. Includes field studies.

PREREQUISITE: BIO 252, CHM 123, CHM 211 RECOMMENDED.

626     HUMAN GENETICS (4)

(Also listed as BMS 780.) Nature of human genetic traits; methods of analysis of inheritance.

PREREQUISITE: BIO 302, 402 OR 403.

629     PLANT ANATOMY (5)

This course will examine the internal structure of vascular plants.Special emphasis will be place on structure-function relationships and their adaptive significance.

PREREQUISITE: BIO 105, 106.

631     RISK ASSESSMENT (3)

Studies the determination of quantitative risk to humans and the environment. Approaches currently used in regulatory activities are described, showing method of hazard identification, sampling, data evaluation, exposure assessment, toxicity assessment, and risk characterization.

PREREQUISITE: MINIMUM OF TWO BIO COURSES AND COMPLETION OF ONE YEAR OF INORGANIC CHEMISTRY.

632     RISK ASSESSMENT II (3)

Follow-up course to BIO 631. Includes key components of risk assessments, such as pharmacokinetic modeling, environmental fate and transport modeling, low dose extrapolation, and risk communication.

PREREQUISITE: BIO 631.

642     ADVANCED MOLECULAR BIOLOGY (3)

Emphasizes gene organization and genome organization focusing on the molecular anatomy, expression, and regulation of eukaryotic genes. Includes a thorough discussion of recombinant DNA technology.

PREREQUISITE: BIO 212, 410, CHM 213.

651 &;nbsp;   ENVIRONMENTAL MANAGEMENT AND RISK COMMUNICATION (3)

Enlarges students’ environmental perspective by focusing on management issues as they relate to air, water, and land resources including ethics, policy, and economics, as well as questions relating to specific resources. Titles vary.

652     ENVIRONMENTAL PROTECTION:LAW, REGULATION AND ENFORCEMENT (3)

Reviews the American legal system, emphasizing regulatory agencies and the courts; environmental and toxic tort case law; and the complex way that the myriad environmental laws and regulations are structured and enforced. Titles vary.

653     NATURAL RESOURCE MANAGEMENT (3)

Lecture/seminar course covering principles of wildlife, fisheries, and forestry management.Major topics include basic ecological principles, population dynamics and analysis, habitat assessment, and ecosystem and people management.

PREREQUISITE: BIO 306.

655     PLANT SYSTEMATICS (3)

A survey of topics and techniques encountered in studies of the relationship and evolution of the higher plants, emphasizing the flowering plants.

PREREQUISITE: BIO 254: SENIOR STANDING OR CONSENT OF PROFESSOR.

660     POPULATION GENETICS (3)

Examination of the causes of genetic differences within and among species and how molecular biology techniques can be used to identify these differences.Emphasized human genetics, anthropology, ecology and conservation implications.

PREREQUISITE: BIO 210, 211, 212, 302.

661     MOLECULAR EVOLUTION (3)

Studies the evolutionary history of organisms by interpreting their genomes as historical documents.Focuses on the origins of human traits and diseases, phylogenetic reconstruction and systematics.

PREREQUISITE: BIO 210, 211, 212, 302.

664     MICROBIOLOGY OF FOOD (3)

Principles of food microbiology, preservation, and handling. Major organisms of food poisoning and means of control are considered.

PREREQUISITE: A COURSE IN MICROBIOLOGY.

666     FUNDAMENTALS OF OCCUPATIONAL HEALTH AND SAFETY (3)

Introduction to accident recognition, evaluation, and control in the work environment, with emphasis on methods of hazard recognition and control management.

PREREQUISITE: MTH 130, CHM 123.

668     ADVANCED OCCUPATIONAL HEALTH AND SAFETY (3)

Introduction to industrial hygiene. Emphasis is on routes of entry into the human body and physiological effects of industrial pollutants.

PREREQUISITE: MTH 130, CHM 123, 211, 215.

670     HANDS-ON SCI WORKSHOP (1 TO 3)

Workshops to enhance science skills for Trotwood-Madison Elementary School teachers.

673     BIOLOGY OF SELECTED MARINE ENVIRONMENTS (5)

Biological aspects of marine environments. Sampling and observation of living marine specimens during week-long trip to a marine laboratory.

676     HUMAN PARASITOLOGY (2)

(Also listed as BMS 799.) Study of the medical aspects of parasitology, such as pathology, symptomatology, diagnosis, and identification of parasites. Course content is divided into three major categories: human protozoology, human helminthology, and human arthropodology. Designed primarily for medical technologists, biology teachers, and environmental health students.

680     BIOLOGY OF FISHES (5)

Introduction to the evolution, ecology, and distribution of fresh water and marine fish. 3 hours lecture, 4 hours lab, and field trips.

684     INTRODUCTION TO BIOGEOGRAPHY (3)

Introduction to the factors affecting the distribution of plants and animals.

PREREQUISITE: BIO 306.

692     ENVIRONMENTAL ISSUES SEMINAR (2)

Seminar provides students with a more in-depth understanding of a number of environmental topics and enhances library research, writing, presentation, and advocacy skills. In addition, students will learn that there are at least two sides to any of the issues discussed.

699     SPECIAL PROBLEMS IN BIOLOGY (1 TO 12)

A maximum of 4 credits is applicable toward degree requirements.

700     PRINCIPLES OF INSTRUCTION IN BIOLOGY (1)

Survey of available instructional materials and discussion of educational theory and techniques leading to more effective instruction.

701     SELECTED TOPICS IN BIOLOGY (1 TO 5)

Topics vary.

702     INTRODUCTION TO RESEARCH (2)

Different research problems under investigation by the faculty are described with respect to objectives, methodology, and progress as examples of scientific methods applied to biology.

703     ADVANCED DEVELOPMENTAL BIOLOGY (4)

Molecular mechanism of development including topics such as cell signaling, pattern formation, terminal differentiation.

PREREQUISITE: BIO 212 OR EQUIVALENT OR PROFESSOR APPROVAL.

720     MAMMALIAN CELL BIOLOGY (4)

(Also listed as BMS 835.) A comprehensive course addressing both the known and theoretical aspects of cellular organization and function. Suitable as an introductory course for graduate study.

728     PHOTOBIOLOGY (3)

Selected topics in photobiology.

730     CELL BIOLOGY (4)

(Also listed as BMS 778.) Provides a survey of basic concepts that are most important for understanding how cells function.

734     MOLECULAR GENETICS (3)

(Also listed as BMS 779.) Study of the replication, organization, and function of nucleic acids with emphasis on the role of nucleic acids in protein synthesis.

737     RECOMBINANT DNA METHODS (6)

(Also listed as BMS 790 and M&I 737.) Microbial and molecular techniques for producing, cloning, and characterizing recombinant DNA molecules; laboratory exercises in gene manipulation to give an understanding of the principles of genetic engineering. Graded pass/unsatisfactory.

740     ELECTRON MICROSCOPY LS (6)

(Also listed as BMS 834.) Introduction to theoretical and practical aspects of transmission electron microscopy. Emphasizes interpretation and evaluation of electron micrographs. 3 hours lecture, 6 hours lab; additional lab time is required. Completion of course in histology or cell biology is required.

799     LITERATURE CRITIQUE (1 TO 6)

Independent project to write a critical review of literature on a specific topic. Graded pass/unsatisfactory.

800     GRADUATE SEMINAR (1)

Topics vary.

899     GRADUATE RESEARCH (2 TO 18)

Supervised thesis research.

Biomedical Engineering/BME

Note: See quarterly class schedule or departmental advisor for further enrollment restrictions, requirements, or special course information. 

619     BIOFLUID MECHANICS (3)

Derivation and use of the basic conservation laws underlying the fluid mechanical behavior of the cardiopulmonary system. Includes applications to the flows of blood, pulmonary air, and extracorporeal fluids.

PREREQUISITE: MTH 233, ME 212, ME 515(315) OR PERMISSION OF PROFESSOR.

620     BIOMEDICAL HEAT AND MASS TRANSFER (3)

Introduces transport phenomena in biomedical engineering and physiological systems. Energy and mass balances together with constitutive and empirical relationships are used in quantifying such topics as body heat loss by various modes, diffusion mass transport and heat/mass transport in applicable technological systems.

PREREQUISITE: BME 619.

622     ENGINEERING BIOPHYSICS (3)

Application of mathematical and engineering techniques toward describing biophysical systems. Topics include cellular transport, electrical properties of membranes, and biophysics of muscle contraction.

PREREQUISITE: EE 521, OR PERMISSION OF PROFESSOR.

628     BIOMECHANICS AND BIOTHERMODYNAMICS (3)

Application of solid mechanics and thermodynamics toward describing physiological systems. Topics include mechanics of the skeletal, cardiac, and pulmonary systems and analysis of the biothermal regulation system.

PREREQUISITE: ME 212, ME 515.

639     BIOTRANSPORT AND ARTIFICIAL ORGANS (4)

Introduction to transport processes vital to the design of medical devices for artificial intervention into living systems.Topics include circulatory system dynamics, mathematical modeling of physiological systems, membrane transport and biological/artificial organ design.

PREREQUISITE: BME 620.

640     BIOMATERIALS (4)

Application of properties of materials and solid mechanics to problems and design of medical implants, external prostheses, and living tissues. Topics include mechanical properties of biologic and synthetic materials, stress-strain analysis, viscoelasticity, tissue response to implants and vice versa, and implant materials for interfacing with hard and soft tissues and blood.

PREREQUISITE: ME 213, EE 521(321).

661     BIOINSTRUMENTATION I (4)

Principles of design and analysis of electronic instrumentation for medical applications. Topics include various electrodes/transducers for physiological measurement and electrical stimulation, biological signal acquisition and processing, various medical imaging modalities/systems, and electrical safety. 3 hours lecture, 2 hours lab.

PREREQUISITE: BIO 279, EE 321, BME 460 OR EQUIVALENT.

662     BIOINSTRUMENTATION II (4)

Continuation of principles of design and analysis of electronic instrumentation for medical applications. Topics include various electrodes/transducers for physiological measurement and electrical stimulation, biological signal acquisition and processing, various medical imaging modalities/systems, and electrical safety. 3 hours lecture, 2 hours lab.

PREREQUISITE: BME 661.

663     BIOMEDICAL COMPUTERS I (2)

Digital computer applications in biomedical related fields. Use of software to solve biomedical problems and display results.

PREREQUISITE: CEG 220, EE 501(301).

664     MICROPROCESSORS FOR BIOMEDICAL ENGINEERING (4)

Examines principles, hardware structure, and programming techniques of microprocessors, applications of microprocessor-based systems in hospitals, rehabilitation engineering and medical research.

PREREQUISITE: BME 663(463).

670     PHOTON RADIATION (3)

Introduces generation, effects, and detection of ionizing radiation and its application to medicine. Completion of this course fulfills the educational requirement to be a user of radioactive materials and radiation-producing devices.

PREREQUISITE: PHY 242, 244, BIO 279.

671     MEDICAL IMAGING (3)

An overview is given over the various methods used in generating images in medicine.The basic principles of the image forming process are discussed as well as the physical properties of the resuntant image.

699     SPECIAL PROBLEMS IN BIOMEDICAL ENGINEERING (1 TO 5)

Special problems in advanced engineering topics. Titles vary.

711     ADVANCED BIOMECHANICS (3)

Covers a variety of mathematical models that have been developed to describe muscle performance in health and disease.

PREREQUISITE: BME 428 OR BME 628 OR PERMISSION OF PROFESSOR.

712     CARDIOPULMONARY MODELING (3)

(Also listed as BMS 951.) Acquaints students with the analytical, numerical, and experimental methods used in modeling the quantitative behavior of physiological and artificial organ systems, particularly the circulation and the lungs.

PREREQUISITE: BME 440, 439 OR BME 640, 639.

713     BIOCOMPATIBILITY OF MATERIALS (3)

(Also listed as BMS 952.) Acquaints students with the concept of biocompatibility of materials, including effects on biological systems. Also deals with the general problem of selection, qualification, and specification of materials.

PREREQUISITE: BME 640(440), BIO 209 OR EQUIVALENT.

731     MEDICAL ULTRASONICS (3)

(Also listed as BMS 956.) Fundamentals of medical ultrasonics: ultrasound generation, propagation, scattering, and attenuation in biological tissue. A-mode, B-mode, M-mode, and Doppler imaging techniques. Ultrasound tissue characterization and quantitative imaging techniques.

PREREQUISITE: PHY 244, EE 521(321).

732     COMPUTED TOMOGRAPHY (3)

(Also listed as BMS 957.) Principles of generating images from projections. Discussion of the various scanner geometries, mathematical reconstruction, correction procedures, and qualitative and quantitative evaluation of images. Focuses on the medical application of computed tomography.

PREREQUISITE: BME 671(471)–FORMERLY BME 665(465).

733     NUCLEAR MAGNETIC RESONANCE IN MEDICINE (3)

(Also listed as BMS 958.) Principles of imaging and spectroscopy of nuclear magnetic resonance in their applications to medicine. Topics include magnetization models, material encoding, spin interactions, localized spectroscopy, and relaxation.

PREREQUISITE: BME 671(471)–FORMERLY BME665(465).

734     PROCESSING OF MEDICAL IMAGES (3)

(Also listed as BMS 959.) Digital image processing in its application to medical images. Topics include image display, filtering, two-dimensional Fourier transform, restoration, enhancement, and edge detection. Some simple tools from the field of mathematical morphology are also introduced.

PREREQUISITE: BME671(471)–FORMERLY BME 665(465), PREREQ OR COREQUISITE: EE 711.

735     PHOTON EMISSION IMAGING (3)

(Also listed as BMS 960.) Principles of imaging procedures based on radioactive isotopes. Topics include radioactive isotopes, single-photon emission-tomography, and positron emission-tomography. Each topic covers instrumentation, image production, and major applications.

PREREQUISITE: BME 671(471)–FORMERLY BME 665(445).

736     BIOMEDICAL SIGNALS AND PROCESSING (4)

Characteristics and measurement of various biomedical signals; time-domain and frequency-domain, continuous and discrete signal representations; application of digital and random signal processing methods to analysis of biomedical signals.

PREREQUISITE: EE 710, STT 666 OR EQUIVALENT.

740     REHABILITATION ENGINEERING DESIGN I (1)

Presented as a three-quarter sequence to provide knowledge and experience in the rehabilitation engineering design process, research and development process, and funding issues. Limited to students enrolled in the graduate rehabilitation engineering training program.

741     NEUROMUSCULAR ENGINEERING (4)

(Also listed as BMS 961.) Teaches the design and application of neuromuscular assistive devices. Emphasizes biomathematics modeling and control theory.

PREREQUISITE: BME 622 (422) OR PERMISSION OF PROFESSOR.

742     REHABILITATION ASSISTIVE SYSTEMS (3)

(Also listed as BMS 962.) Design and application of devices used in rehabilitation. Provides an understanding of the problems of disabled people and the variety of possible solutions to these problems.

743     INTRODUCTION TO REHABILITATION ENGINEERING (3)

Introduces the complex structure of the rehabilitation engineering service delivery systems practiced in the United States. Covers basic disability areas, current laws, resources, and rehabilitation technology.

745     REHABILITATION ENGINEERING SERVICE DELIVERY (3)

Introduces rehabilitation engineering design principles. Includes practical design experiences in worksite modification, ergonomics, and accessibility evaluations. Provides experience in technical report writing and presentation.

PREREQUISITE: BME 743.

746     REHABILITATION ENGINEERING COMPUTERS I (3)

Introduces object oriented programming structured around the HyperCard, HyperText Macintosh, and ToolBook PC environments. Covers basic principles of programming using objects, cards, windows, projects, and graphics with application to rehabilitation engineering. Introduces PC hardware in detail. Concurrent enrollment in lecture and lab is required.

747     REHABILITATION ENGINEERING DESIGN II (3)

Continuation of BME 745 and BME 746. Focuses on development of computer application programs and devices to aid the disabled.

PREREQUISITE: BME 745 AND BME 746.

748     REHABILITATION ENGINEERING INTRODUCTION TO CLINICAL PRACTICE (4)

Introduces clinical practices and services provided to disabled patients in a rehabilitation center involving various services, testing, and evaluation. Focus is on spinal cord injury and traumatic brain injury.

750     REHABILITATION ENGR (1 TO 5)

Engineering analysis and design are applied on rehabilitation tasks within a clinical setting. Provides training in rehabilitation engineering management of various disabilities. Enrollment in multiple sections is required.

751     HUMAN CONTROL ENGINEERING (4)

Modeling, design and analysis of the physiological and cognitive performance of the human operator.Human-environmental interactions are characterized as biothermal control systems.Human-technological interactions are characterized as informative control systems.

880     SELECTED TOPICS IN SYSTEMS ENGINGEERING (1 TO 5)

Selected topics in current research and recent developments in systems theory and engineering.

890     SPECIAL PROBLEMS IN BIOMEDICAL ENGINEERING (1 TO 5)

Special problems in advanced biomedical engineering topics. Topics vary.

898     PH D DISSERTATION RESEARCH (1 TO 5)

Research on the Ph.D. dissertation topic. Graded pass/unsatisfactory.

899     THESIS (1 TO 5)

Pass/unsatisfactory.

Biomedical Sciences/BMS

Note: See quarterly class schedule or departmental advisor for further enrollment restrictions, requirements, or special course information. 

655     MATRIX ALGEBRA (5)

(Also listed as MTH 655.) Matrices, systems of equations, vector spaces, inner products, linear transformations, determinants, eigenvalues, eigenvectors, quadratic forms, and symmetric matrices.

PREREQUISITE: BMS 698.

664     COMPUTATIONAL STATISTICS (4)

(Also listed as STT 664.) Review of the principles underlying statistical methodology and techniques available for analyzing biomedical data. Emphasizes the necessity for careful design of experiments and the structure of data.

PREREQUISITE: STT 560 & STT 561 OR EQUIVALENT.

668     INTRODUCTION TO SAS (2)

Introduces the use of the statistical analysis system (SAS), a statistical computing package widely used in industry, government, and academia.

PREREQUISITE: BMS 666 OR EQUIVALENT.

698     BIOMEDICAL COMPUTER SCIENCE (4)

Introduces programs such as SYMVU, CSMP, and ORTEP, which create plotted output. FORTRAN is also introduced. Problems and data used are from the life sciences. Graded pass/unsatisfactory. Enrollment in Biomedical Sciences Ph.D. program required.

703     RESEARCH ETHICS (1)

(Also listed as BMB 703.) Research ethics emphasizes the evaluation of hypothetical ethical scenarios. Class discussion is based on integrating ethical policy and practices as they relate to research at Wright State. Graded pass/unsatisfactory.

705     LINEAR SYSTEMS I (4)

(Also listed as EE 701 and EGR 701.) Signal representation, orthonormal bases, and generalized Fourier series. Description of linear, discrete, and continuous systems. Systems analysis via classical equations, convolution, and transform methods.

PREREQUISITE: BMS 664 AND 698.

706     LINEAR SYSTEMS II (3)

(Also listed as EE 702.) State variable representations of continuous and discrete systems. Linear vector spaces and similarity transformations; eigen-analysis, time and transform domain solutions of linear state equations; controllability, observability, and stability of linear systems.

PREREQUISITE: BMS 705.

708     DIGITAL SIGNAL PROCESSING (4)

Data Acquisition and Quantization, Unitary Transforms, Circular Convolution, Hilber Transform, FIR/IIR Filter Design and Realization, Analysis of Finite=Precision Numerical Effects, Spectral Estimation Cepstrum Analysis.

PREREQUISITE: BMS 706.

710     CONTROL SYSTEMS I (3)

(Also listed as EE 613.) Provides students with a general control background. Major topics include block diagrams and signal-flow graphs, electromechanical modeling including state variable representation, time response, root locus, and introduction to design.

PREREQUISITE: BMS 664 AND 698. COREQUISITE: BMS 711.

712     CONTROL SYSTEMS II (3)

(Also listed as EE 615.) Using Control Systems I background, course concentrates on controller design, in both the time and frequency domains, using NYquist, Bode, root locus and state variable techniques. Digital control concepts are introduced.

PREREQUISITE: BMS 710 AND 711. COREQUISITE: BMS 713.

725     PHYSICAL POLYMER CHEMISTRY (3)

(Also listed as CHM 665.) Introduction to the structural and physical aspects of macromolecules; emphasis on the relationship of polymer structure to physical and mechanical properties.

PREREQUISITE: CHM 213 OR CHM 561.

726     SYNTHETIC POLYMER CHEMISTRY (3)

(Also listed as CHM 661.) Step-growth and chain-growth polymerization in homogeneous and heterogeneous media; properties of commercial polymers.

PREREQUISITE: CHM 213 OR CHM 561.

727     PHYSICAL POLYMER CHEMISTRY LABORATORY (1 TO 2)

(Also listed as CHM 667.) Laboratory illustrations of BMS 725 lecture material and techniques of polymer science.

PREREQUISITE: CHM 213 OR CHM 561.

728     POLYMER SYNTHESIS LABORATORY (1 TO 2)

Laboratory illustrations of BMS 726 lecture material and techniques of polymer science.

PREREQUISITE: CHM 213 OR CHM 561.

733     ADVANCED INORGANIC CHEMISTRY I (3)

(Also listed as CHM 720.) Study of atomic structure, modern theories of chemical bonding, and structural concepts of inorganic chemistry and their relationships to reactivity, acids and bases in aqueous and nonaqueous systems, and energetics of reactions.

734     ADVANCED INORGANIC CHEMISTRY II (3)

(Also listed as CHM 721.) Thorough examination of coordination chemistry of the metals stressing transition elements, crystal and ligand field approaches and molecular orbital theory as applied to organometallic systems, mechanisms of inorganic reactions, and the role of metal ions in biological systems.

PREREQUISITE: BMS 733.

735     ADVANCED INORGANIC CHEMISTRY III (3)

(Also listed as CHM 722.) Survey of the applications of physical methods in the examination and characterization of inorganic compounds. Emphasis is on methods applied to transition metal complexes.

PREREQUISITE: BMS 734.

736     CHEMICAL KINETICS (3)

(Also listed as CHM 751.) Characterization of simple kinetic systems, experimental methods, energy distributions in molecules, the transition state method, and chain reactions in solution.

PREREQUISITE: CHM 453 OR EQUIVALENT.

737     CHEMICAL THERMODYNAMICS (3)

Fundamentals; first, second, and third laws; and application to solutions.

PREREQUISITE: CHM 453 OR EQUIVALENT.

738     SELECTED TOPICS IN PHYSICAL CHEMISTRY (3)

(Also listed as CHM 855.) Selected topics in the field of physical chemistry such as molecular spectroscopy, advanced molecular structure, magnetic resonance, X-rays and crystal structure, statistical mechanics, or precise physical-chemical measurements.

740     ADVANCED BIOANALYTICAL CHEMISTRY (3)

An introduction to control systems using state variables and classical analysis.Closed loop system representation, block diagrams, time response, and frequency response are treated.

PREREQUISITE: BMS CORE.

741     STRUCTURAL CONCEPTS IN ORGANIC CHEMISTRY (3)

Study of molecular orbital theory, reactive species, theories of acids and bases, and an introduction to stereochemistry.

742     INSTRUMENTATION (3)

Introduction to the theory and practices of modern chemical instrumentation; elementary electronics, spectrophotometry, atomic absorption, electrochemical techniques, chromatography, and other instrumental techniques.

750     BIOCHEMISTRY AND MOLECULAR BIOLOGY I (4 TO 10)

(Also listed as BMB 750.) Survey course emphasizing an experimental and problem-solving approach to buffers, protein structure, enzymes, and carbohydrate and lipid metabolism.

752     BIOCHEMISTRY AND MOLECULAR BIOLOGY II (3 TO 10)

(Also listed as BMB 752.) Survey course emphasizing an experimental and problem-solving approach to amino acid metabolism, nucleic acid function, and hormones.

PREREQUISITE: BMS 750 OR PERMISSION OF PROFESSOR.

753     MOLECULAR SIGNALLING-MOLECULAR CELL BIOLOGY (3)

(Also listed as BMB 753.) A molecular analysis of information transfer into and within cells. Topics include visual transduction, hormones, hormone receptors, second messengers, regulation of transcription, and oncogenes. Readings from current scientific literature.

PREREQUISITE: BMS 750, BMS 752.

755     CANCER: MOLECULAR ASPECTS (2 TO 6)

A profile of the general properties of transformed cells and an in-depth examination of the mechanisms of oncogenesis at eht level of molecular genetics.

PREREQUISITE: BMS CORE.

760     MOLECULAR BIOLOGY OF THE NUCLEUS (4)

(Also listed as BMB 760.) A literature-based course covering molecular events in the nucleus including DNA replication, repair, recombination, and transcription.

PREREQUISITE: BMB 750, BMB 752.

762     FUNDAMENTAL PRINCIPLES OF FOURIER TRANSFORM NMR (3 TO 6)

(Also listed as BMB 762/PHY 760.) Covers the fundamental theory of nuclear magnetic resonance spectroscopy with emphasis on pulse Fourier transform methods.

PREREQUISITE: BMS CORE.

763     IN VIVO NMR SPECTROSCOPY AND IMAGING (3 TO 6)

(Also listed as BMB 763.) Discusses the applications of NMR spectroscopy to the study of tissue metabolism in vivo. The fundamental theory of magnetic resonance imaging, with a survey of clinical applications, are also presented.

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PREREQUISITE: BMS CORE.

764     NMR TECHNIQUES IN BIOMOLECULAR STRUCTURE AND DYNAMICS (3 TO 6)

(Also listed as BMB 764.) Describes the NMR methods used for the determination of biomolecular structure and dynamics. Emphasis on two-dimensional Fourier transform techniques.

PREREQUISITE: BMS CORE.

765     COMPUTATIONAL TOOLS AND STRATEGIES IN BIOMED SCIENCES (4)

This is a survey course of modern computational tools and strategies used in sequence, 3-D structure and funcional analysis of biomolecules.Students will gain hands on “laboratory” experience with key software and strategies.

PREREQUISITE: ENROLLMENT IN BMS PROGRAM OR PROFESSOR PERMISSION REQUIRED.

767     ENZYMES (4)

(Also listed as BMB 727.) Mechanism of enzyme catalysis, including such topics as structure, kinetics, energetics, allosterism, co-enzymes, and control of enzymes and multienzyme systems.

PREREQUISITE: BMS 750.

768     BIOCHEMISTRY OF PEPTIDE HORMONES (3)

Synthesis, secretion, degradation, structure assay, mechanism of action, and function of peptide hormones are presented. Emphasis is on insulin and other hormones involved in diabetes mellitus.

PREREQUISITE: BMS 752.

769     BIOCHEMISTRY OF MEMBRANES (4)

(Also listed as BMB 731.) Examines the biochemistry of membranes and provides basic information on membrane composition and processes.

PREREQUISITE: BMS 750 AND 835.

770     PHYSICAL BIOCHEMISTRY (4)

(Also listed as BMB 740.) Structure-function analysis of biological macromolecules (particularly proteins and polynucleotides) based on chemical and physical properties.

PREREQUISITE: BMS 750.

771     SAFE USE OF RADIONUCLIDES (2)

Principles of a, b, and g radiation and methodology of counting with application to physical and biological problems.

775     PATHOGENIC MECHANISMS (5)

(Also listed as M&I 675.) Expands knowledge of basic microbiology by focusing on human-microbial pathogen interactions. The molecular basis of the pathogenic mechanisms will be emphasized. In addition, the student will gain a better appreciation and understanding of the complexities of interactions between microbes and their human hosts.

PREREQUISITE: BIO 210 OR EQUIVALENT MOLECULAR BIOLOGY COURSE AND BIO 252 OR EQUIVALENT INTRODUCTORY MICROBIOLOGY COURSE.

776     BIOENERGETICS (1 TO 6)

Structure of energy-transducing membranes of mitochondria, chloroplasts, and bacteria. Emphasis on mechanisms of energy transduction, thermodynamics of oxidation-reduction reactions, biophysical spectroscopic methods, and structure and surface topography of membrane proteins.

PREREQUISITE: BMS 752.

777     GENE THERAPY (4)

(Also listed as M&I 777.) Study of the molecular basis of gene therapy and the use of viral gene delivery systems for the treatment of human disease. Gene therapy strategies are contrasted with various diseases, including cancer and AIDS.

778     CELL BIOLOGY (4)

(Also listed as BIO 730.) Provides a survey of basic concepts that are most important for understanding how cells function.

779     MOLECULAR GENETICS (3)

(Also listed as BIO 734.) Study of the replication, organization, and function of nucleic acids with emphasis on the role of nucleic acids in protein synthesis.

PREREQUISITE: BMS CORE COURSES.

780     HUMAN GENETICS (4)

(Also listed as BIO 626.) Nature of human genetic traits, methods of analysis of inheritance, principles of counseling, and therapy.

PREREQUISITE: BMS 752 AND 835.

785     ADVANCED SEMILNAR IN GENETICS (2)

Review of current literature in molecular or human genetics subjects. Presentation of reviews to other students.

PREREQUISITE: BMS 780.

786     BEHAVIOR GENETICS (3)

Behavior is considered as a population phenomenon and as an adaptive process. Evolutionary theory is used to integrate the disparate aspects of behavioral phenomena.

PREREQUISITE: BMS 780.

790     RECOMBINANT DNA METHODS (6)

(Also listed as BIO 737 and M&I 737.) Microbial and molecular techniques for producing, cloning, and characterizing recombinant DNA molecules; laboratory exercises in gene manipulation to give an understanding of principles of genetic engineering. Graded pass/unsatisfactory.

PREREQUISITE: BMS CORE.

791     MICROBIAL GENETICS (3)

Basic concepts of production of microbial mutations and their detection and analysis. The use of microbial genetics in elucidating cellular functions; the construction of plasmids and their use in genetic engineering.

PREREQUISITE: BMS 752 AND 835.

793     MICROBIAL ECOLOGY (5)

(Also listed as BIO 625.) Microbes in soil, water, and air. Experiments on mineral cycles, physical and biological limiting factors, and symbiosis. Natural communities of microbes and microbes of special human environments. Includes field studies.

799     HUMAN PARASITOLOGY (2)

(Also listed as BIO 676.) Study of the medical aspects of parasitology such as pathology, symptomatology, diagnosis, and identification of parasites. Course content is divided into three major categories: human protozoology, helminthology, and arthropodology.

802     IMMUNOLOGY AND BASIC VIROLOGY (5)

(Also listed as M&I 726.) Fundamentals of immunobiology and basic virology. Emphasis on regulatory and cellular levels of host immune responses against microbial pathogens as well as mechanisms of immunopathology. Characteristics and molecular biology of virus pathogens.

PREREQUISITE: BMS 752 AND 835.

803     PATHOGENIC MICROBIOLOGY (5)

(Also listed as M&I 727.) Study of microorganisms that are pathogenic for humans and animals using the organ system approach. Emphasis on mechanisms of pathogenesis and host resistance. Includes a project segment devoted to the independent study of the mechanisms of pathogenesis in the host-parasite interactions of the infectious agents used.

PREREQUISITE: BMS 752 AND 835 OR EQUIVALENT.

805     INTERCELLULAR COMMUNICATION (4)

(Also listed as M&I 770, PHA 740, P&B 776.) Introduces concepts of intercellular communication through an interdisciplinary presentation of immune and neuroendocrine system functions. Emphasizes the similarities between the systems and the multidisciplinary approaches used to study each.

807     BASIC VIROLOGY (3)

(Also listed as M&I 731.) Introduction to the field of virology with emphasis on animal viruses. Studies the intrinsic properties of viruses and their interaction with cells; multiplication, disease production, genetics, and tumor induction.

PREREQUISITE: BMS CORE.

808     MOLECULAR VIROLOGY SEMINAR (3)

(Also listed as M&I 831.) Structure, infectious process, replication, maturation, release, and genetics at the molecular level of the major groups of animal viruses.

PREREQUISITE: BMS 752 AND 835.

809     VIRAL ONCOLOGY SEMINAR (3)

(Also listed as M&I 833.) Provides an understanding of the process involved in cell transformation by oncogenic viruses.

PREREQUISITE: BMS 752 AND 835.

812     IMMUNOBIOLOGY (5)

(Also listed as M&I 745.) Study of the biology of the immune system, as well as its function in health and disease. Specific diseases are used as models for immunologically mediated conditions.

PREREQUISITE: BMS 752 AND 835.

813     SPECIAL TOPICS IN IMMUNOLOGY (2 TO

(Also listed as M&I 840.) Students select, present, and analyze information from the current literature in immunobiology.

PREREQUISITE: BMS 752 AND 835.

818     INFECTION AND IMMUNITY SEMINAR (3)

(Also listed as M&I 846.) Deals with the effects of microbial and metazoan parasites on both host resistance and immunologically mediated disease processes.

PREREQUISITE: BMS 752 AND 835.

834     ELECTRON MICROSCOPY FOR LIFE SCIENCE (6)

(Also listed as BIO 740.) Introduction to theoretical and practical aspects of transmission electron microscopy. Emphasis on interpretation and evaluation of electron micrographs. 3 hours lecture, 6 hours lab; additional lab time is required.

PREREQUISITE: PREVIOUS COURSE IN HISTOLOGY OR CELL BIOLOGY.

835     MAMMALIAN CELL BIOLOGY (4 TO 10)

(Also listed as BIO 720.) Interdisciplinary survey of cellular functions, including location of molecular events and functional compartmentation within the cell, recognition of structural and functional elements of the cell, and interaction of cells in specialized tissues.

PREREQUISITE: BMS 750 COREQUISITE.

837     HUMAN GROSS ANATOMY (9)

(Also listed as ANT 711.) Lectures and dissection of human cadaver.

838     MICROANATOMY (8)

Introduction to basic cell structure, including membranes, nucleus, and cytoplasmic organelles. Emphasis on the detailed histological anatomy of the four basic tissues, and major organs and systems of the body.

PREREQUISITE: BMS 751.

839     DEVELOPMENTAL BIOLOGY (3 TO 6)

(Also listed as BIO 603.) Describes underlying processes that initiate the development of tissue and whole organisms in plants and animals.

PREREQUISITE: RECOMMEND BIO 402, BIO 303 OR THE EQUIVALENT.

840     REPRODUCTIVE ANATOMY AND PHYSIOLOGY (3)

Reproductive cycles and gametogenesis; intercourse and conception; events of pregnancy and parturition; contraception, sterility, and dysfunction.

PREREQUISITE: BMS CORE.

850     BASIC HUMAN PHYSIOLOGY I (4 TO 10)

Basic course in structure, function, and interactions of human organ systems. Subject areas include musculoskeletal, neurological, cardiovascular, and respiratory systems.

PREREQUISITE: BMS 752 AND 835.

851     BASIC HUMAN PHYSIOLOGY II (4 TO 10)

Basic course in structure, function, and interactions of human organ systems. Subject areas include endocrine, gastrointestinal, urinary, and reproductive systems.

PREREQUISITE: BMS 850.

852     CELL PHYSIOLOGY AND BIOPHYSICS (4)

(Also listed as P&B 601.) Fundamentals of cellular homeostasis and the role of specialized cells in organismal homeostasis.

PREREQUISITE: ADMISSION TO THE BMS PROGRAM.

853     ION CHANNELS (4)

(Also listed as P&B 722.) Explores the role of ion channels in a variety of cell types with an emphasis on both electrophysiological and biochemical methods for evaluation of channel function.

PREREQUISITE: BMS 852 AND/OR PERMISSION OF PROFESSOR.

854     MEDICAL NEUROSCIENCE (7)

(Also listed as ANT 777 and P&B 777.) Interdisciplinary/interdepartmental course for medical and graduate students that integrates basic and clinical neurosciences. Structural and functional topics are combined with clinical information to address major neurological and psychiatric disorders.

PREREQUISITE: BMS CORE COURSES.

856     GLIAL CELL PHYSIOLOGY (3)

(Also listed as P&B 650.) Concepts of glial cell physiology based on the analysis of current primary literature. Topics include interaction between glia and other cell types and the role of glia in pathophysiology.

PREREQUISITE: P&B 642.

859     GASTROINTESTINAL PHYSIOLOGY AND BIOPHYSICS (3)

(Also listed as P&B 761.) Principles of gastrointestinal physiology and biophysics emphasizing cellular mechanisms of secretions, absorption, and motility.

PREREQUISITE: BMS CORE.

860     GENERAL ENDOCRINOLOGY (3)

(Also listed as P&B 771.) Survey of endocrinological mechanisms and their role in integration of body function.

PREREQUISITE: BMS 851 OR PERMISSION OF PROFESSOR.

862     HUMAN PHYSIOLOGY (5)

(Also listed as P&B 610.) An overview of human/mammalian organ system physiology. Fundamental mechanisms and the experimental basis for current understanding are emphasized.

864     PHYSIOLOGICAL ASPECTS OF EXERCISE (5)

(Also listed as P&B 783.) Integration of physiological mechanisms involved in exercise. Cellular, neuromuscular, cardiovascular, and respiratory changes are discussed with relationship to exercise performance.

PREREQUISITE: BMS CORE.

865     INTRODUCTORY NEUROPHYSIOLOGY (4)

(Also listed as P&B 642.) Physiological mechanisms that subserve the functions of the nervous system. Topics include the biophysics of neuronal information, intercellular communications, motor control, sensory systems, and development neurobiology.

PREREQUISITE: BMS 852.

866     CARDIOVASCULAR PHYSIOLOGY (3)

(Also listed as P&B 733.) Survey of the physiology of the human cardiovascular system; components and control, cell, organ, and system level. Both newborn and adult are included, as well as adjustments to exercise and non-exercise stress.

PREREQUISITE: ENROLLMENT IN THE BMS PH.D. PROGRAM.

867     FLUORESCENCE: THEORY AND PRACTICE (1 TO 3)

(Also listed as P&B 704.) Covers the theoretical basis for fluorescence and instrument design in this methods-oriented course. Applications of interest to the physiological and biochemical sciences are discussed.

PREREQUISITE: BMS 750; BMS 752.

868     MOLECULAR BASIS OF SECRETION (1 TO 5)

(Also listed as P&B 751.) Explores current hypothesis for the formation, sorting, and release of secretory vesicles at a molecular level of integrating ideas from cell biology, neuroscience, and membrane biophysics. Methodology is emphasized.

PREREQUISITE: BMS 852.

869     QUANTITATIVE ASPECTS OF MEMBRANE TRANSPORT (3 TO 10)

(Also listed as P&B 669.) Employs a quantitative approach to the properties of solutes, water, bio-electrical phenomena, transport systems that move solutes across biological membranes, and the interactions of these solutes with membranes. May be taken for letter grade or pass/unsatisfactory.

PREREQUISITE: BMS 835 AND BMS 852.

870     PHYSIOLOGY AND PHARMACOLOGY OF VASCULAR CELLS (3)

(Also listed as PHA 870 and P&B 870.) Study of physiological steady state and pharmacological properties of vascular cells-circulating erythrocytes, endothelial cells, and smooth muscle cells in particular-as a basis of pathologic aberrations and clinical disorders.

PREREQUISITE: CELL BIOLOGY, CELL BIOPHYSICS, OR EQUIVALENT.

876     PRINCIPLES OF BIOKINETICS (4)

Abbreviated course describing passage of drugs across membranes, their mechanisms of action, distribution, biotransformation, and elimination. Discusses dose-response relationships, receptor-binding kinetics, and topics of interest and importance to enrolled students.

879     MOLECULAR PHARMACOLOGY (4)

Introduces students to drug-receptor interactions, dose-response relationships, physiochemical principles of drug action and distribution, pharmacokinetics, mechanisms of action, and uses of drugs affecting both autonomic and central nervous system functions.

PREREQUISITE: BMS CORE.

880     GENERAL PHARMACOLOGY II (4)

(Also listed as PHA 880.) Extends the principles and theoretical considerations learned in BMS 879 and applies them to the action of drugs on the cardiovascular, respiratory, endocrine, gastrointestinal, and genito-urinary systems. Emphasis on antibiotics, chemotherapy of infectious diseases, antineoplasia, and immuno-suppressants. An introduction to toxicology is provided.

PREREQUISITE: BMS 879.

881     RESEARCH TECHNIQUES (3)

Practical laboratory experience in commonly used biological techniques including DNA purification and manipulation, protein expression and analysis, and the classical pharmacological technique of measuring receptor binding.Designed to give hands on experience along with a short weekly lecture providing background on the theory behind the topic.

886     GENERAL PATHOLOGY (7)

Introduces basic principles of abnormal biological processes in the human and subhuman vertebrate organisms. Deals with tissue injury and degeneration, abnormal growth, infection and host defense, selected metabolic and congenital disorders, and forensic problems. Complies with the Toxicology Society’s recommended requirements for the professional toxicologist.

PREREQUISITE: BMS CORE.

887     MOLECULAR TOXICOLOGY (4)

Introduction to general toxicology covering the principles of intoxication and detoxication, classification of poisons, exposure characteristics, biotransformation and biokinetics of poisons, systemic toxicology including central nervous system, splanchnic organs, cardiovascular, hematopoietic, respiratory, reproductive, and skeletal systems.

PREREQUISITE: BMS 880.

888     GENERAL TOXICOLOGY II (4)

(Also listed as PHA 752.) Introduction to general toxicology. Particular toxic agents are studied, including teratogens, mutagens, oncogens, heavy metals, and other environmental contaminants and toxins. Clinical, forensic, industrial, and agricultural toxicology are addressed along with regulations that apply to the field.

PREREQUISITE: BMS 887.

889     TOXICOLOGIC PATHOLOGY (3)

The pathobiology of toxic chemicals and materials is presented with emphasis placed on anatomic and physiologic changes produced in common laboratory animal species.Research methods enhancing the pathologic evaluation of biomedical specemens will be stressed.

PREREQUISITE: BMS 886.

890     PRINCIPLES OF BIODYNAMICS (4)

Covers the general basis of toxicology and therapeutics: pharmacokinetics, xenobiotic metabolism, and their effects on determination of the dose-response-time relationship.

PREREQUISITE: CORE CURRICULUM OR EQUIVALENT OR PERMISSION OF PROFESSOR.

898     NEUROPHARMACOLOGY (3)

(Also listed as PHA 898.) In-depth treatment of the anatomy, biochemistry, physiology, and function of neurotransmitter systems and the effects of drugs on the nervous system.

PREREQUISITE: BMS CORE AND BMS 876 OR EQUIVALENT OF BOTH, PLUS PERMISSION OF DIRECTOR.

902     NEUROPHYSIOLOGY (3)

(Also listed as P&B 720.) Survey of neurophysiology with emphasis on somatic and autonomic control of body function.

PREREQUISITE: BMS CORE.

903     HUMAN NEUROANATOMY (7)

(Also listed as ANT 731.) Detailed survey of the anatomy and physiology of the major fiber tracts and cell groups of the human central nervous system.

PREREQUISITE: BMS CORE.

905     INFORMATION PROCESSING (4)

(Also listed as PSY 665.) Survey of experimental findings in animal and human memory with emphasis on their implications for current theories of memory.

PREREQUISITE: BMS CORE.

910     PSYCHOBIOLOGY OF STRESS (4)

(Also listed as PSY 619.) Detailed examination of selected areas in cognition and learning.

PREREQUISITE: BMS CORE CURRICULUM.

913     FUNDAMENTALS OF HUMAN NEUROBIOLOGY (4)

(Also listed as ANT 691.) Development, structure, and function of the human nervous system as it relates to neuropathology, clinical neurology, and behavioral science.

PREREQUISITE: GENERAL BIOLOGY AND/OR GENERAL PSYCHOLOGY.

914     BEHAVIORAL NEUROSCIENCE (4)

(Also listed as PSY 891.) Covers neurobiological bases of behavior. Focuses on motor function, ingestion, mating, learning, memory, rhythmical influences, and emotion.

PREREQUISITE: BMS CORE OR EQUIVALENT.

925     FUNDAMENTALS OF BIOLOGICAL COMPUTATION AND MODELING (5)

This course will treat fundamental programming approches, data structures and mathematical/statistical principles used in designing computational biology tools and algorithms.Students will learn theoretical principles and gain practical experience.

PREREQUISITE: ADMISSION REQUIREMENTS FOR BMS PROGRAM PLUS PROGRAMMING EXPERTISE.

950     CARDIAC MECHANICS (1 TO 6)

This course teaches BMS Ph.D students a variety of mathematical models which have been developed to describe cardiac performance in health and disease.

PREREQUISITE: BMS CORE.

951     CARDIOPULMONARY MODELING (1 TO 6)

(Also listed as BME 712.) Acquaints students with the analytical, numerical, and experimental methods used in modeling the quantitative behavior of physiological and artificial organ systems, particularly the circulation and the lungs.

PREREQUISITE: BMS CORE.

952     BIOCOMPATIBILITY OF MATERIALS (1 TO 6)

(Also listed as BME 713.) Acquaints students with the concept of biocompatibility of materials, including effects on biological systems. Deals with the general problem of selection, qualification, and specification of materials.

PREREQUISITE: BMS CORE.

953     HUMAN FACTORS ENGINEERING ADVANCED AEROSPACE SYSTEMS DESIGN (1 TO 6)

(Also listed as HFE 724.) Qualifies students to make significant human factors contributions to the design of state-of-the-art aerodynamic and space systems. Design of control-display integration, cockpit configuration, maintainability, and reliability emphasized.

PREREQUISITE: BMS CORE.

954     HUMAN FACTORS ENGINEERING WORKLOAD ANALYSIS (1 TO 6)

(Also listed as HFE 725.) Provides students with tools required to accomplish a workload analysis as a requisite to a systems design or a redesign of an existing system.

PREREQUISITE: BMS CORE.

955     HUMAN FACTORS ENGINEERING: CREW STATION DESIGN (1 TO 6)

(Also listed as HFE 726.) In-depth treatment of human factors engineering principles applicable to design of crew command centers for aerodynamics, space, and maritime systems.

PREREQUISITE: BMS CORE.

956     MEDICAL ULTRASONICS (1 TO 6)

(Also listed as BME 731.) Fundamentals of medical ultrasonics: ultrasound generation, propagation, scattering, and attenuation in biological tissue. A-mode, B-mode, M-mode, and Doppler imaging techniques. Ultrasound tissue characterization and quantitative imaging techniques.

PREREQUISITE: BMS CORE.

957     COMPUTED TOMOGRAPHY (1 TO 6)

(Also listed as BME 732.) Principles of generating images from projections. Discussion of the various scanner geometries, mathematical reconstruction, correction procedures, and qualitative and quantitative evaluation of images. A major focus is the medical application of computed tomography.

PREREQUISITE: BMS CORE.

958     NUCLEAR MAGNETIC RESONACE IN MEDICINE (1 TO 6)

(Also listed as BME 733.) Principles of imaging and spectroscopy of nuclear magnetic resonance in their application to medicine. Topics include magnetization models, material encoding, spin interactions, localized spectroscopy, and relaxation.

PREREQUISITE: BMS CORE.

959     PROCESSING OF MEDICAL IMAGES (1 TO 6)

(Also listed as BME 734.) Digital image processing in its application to medical images. Topics include image display, filtering, two-dimensional Fourier transform, restoration, enhancement, and edge detection. Some simple tools from the field of mathematical morphology are also introduced.

PREREQUISITE: BMS CORE.

960     PHOTON EMISSION IMAGING (1 TO 6)

(Also listed as BME 735.) Principles of imaging procedures based on radioactive isotopes. Topics include radioactive isotopes, single-photon emission tomography, and positron-emission tomography. Instrumen-tation, image production, and major applications are covered.

PREREQUISITE: BMS CORE.

961     NEUROMUSCULAR REHABILITATION ENGINEERING (1 TO 6)

(Also listed as BME 741.) Teaches the design and application of neuromuscular assistive devices. Biomathematics modeling and control theory are emphasized.

PREREQUISITE: BMS CORE.

962     REHABILITATION ASSISTIVE SYSTEMS (1 TO 6)

(Also listed as BME 742.) Design and application of devices used in rehabilitation. Provides an understanding of the problems of disabled people and the variety of possible solutions to these problems.

PREREQUISITE: BMS CORE.

963     APPLICATION OF HUMAN FACTORS ENGINEERING TO REHABILITATION (1 TO 6)

(Also listed as HFE 743.) Teaches students application of human factors design concepts to the design of aids for the physically handicapped. In addition to aids for manipulation of locomotion, barrier-free designs are emphasized.

PREREQUISITE: BMS CORE.

964     AEROSPACE MEDICINE HUMAN FACTORS (3)

Designed for BMS students who are residents of the Aerospace Medicine Program. Seminar focuses on recent developments in human factors engineering. Addresses design principles, crew compartment technology and resource management, crew members performance and reliability.

PREREQUISITE: BMS CORE AND PERMISSION OF PROGRAM DIRECTOR.

965     HUMAN FACTORS ENGINEERING ADVANCES IN VISUAL DISPLAY DESIGN (3)

Application of human factors engineering principles to the design of visual display systems.Discusses current display technologies, human vision, design of display parameters, and image quality metrics.

PREREQUISITE: BMS CORE.

966     ADVANCED TOPICS IN HUMAN-COMPUTER INTERACTION (3)

This graduate-level seminar exposes students to theoretical and research issues associated with human-computer interaction (HCI) and cognitive-oriented work from a human factors engineering standpoint.

PREREQUISITE: BMS CORE.

967     ADVANCED DEVELOPMENT BIOLOGY (4)

Molecular mechanism of development, including topics such as; cell signalling, pattern formation, terminal differntation.

PREREQUISITE: BIO 210, 211, 212 OR EQUIVALENT, OR PROFESSOR APPROVAL.

990     BIOMEDICAL SCIENCES SEMINAR (1 TO 3)

(Also listed as P&B 808.) Convention of student body and faculty in biomedical sciences to learn, discuss, and critique the basic and clinical biomedical literature as presented by an active and reputable scientific investigator. Student presentations required.

991     SPECIAL TOPICS (1 TO 15)

Selected topics in biomedical sciences.

994     INTRODUCTION TO RESEARCH (1 TO 6)